Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Leukemoid Reaction in Association with Bone Marrow Necrosis due to Metastatic Prostate Cancer
Taichi AZUMAIkuya SAKAITakuya MATSUMOTOAkira OZAWANozomu TANJIAkito WATANABENaoyuki UCHIDAHirosi NARUMIYoshihiro YAKUSHIJINTakaaki HATOMasaki YASUKAWAShigeru FUJITA
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2005 Volume 44 Issue 10 Pages 1093-1096

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Abstract

An 80-year-old man presented to the internist with fever, fatigue and leukocytosis up to 66.8×103/μl. Although a chronic myelogenous leukemia was initially suspected, he was diagnosed as metastatic bone marrow tumor with bone marrow necrosis from primary prostate cancer on the basis of the clinical and pathological findings. The serum concentrations of IL-6 and TNF-α were mildly elevated to 65.0 pg/ml and, 54.0 pg/ml respectively. It is probable that these humoral factors were partially responsible for the leukemoid reaction although other factors induced by the bone marrow necrosis with bone marrow metastasis of prostate cancer are also likely involved.

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© 2005 by The Japanese Society of Internal Medicine
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