Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
ORIGINAL ARTICLES
Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance
Shinzo MIYAMOTOHiroaki KAWANOJun HOKAMAKIHirofumi SOEJIMASunao KOJIMATakashi KUDOHYasuhiro NAGAYOSHISeigo SUGIYAMATomohiro SAKAMOTOMichihiro YOSHIMURAHajime NAKAMURAJunji YODOIHisao OGAWA
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JOURNALS OPEN ACCESS

2005 Volume 44 Issue 11 Pages 1127-1132

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Abstract

Objective The aim of the present study was to determine the effects of glucose intolerance on oxidative stress in patients with coronary artery disease (CAD).
Methods The patients were divided into 3 groups, diabetes mellitus (DM), IGT or normal glucose tolerance (NGT) according to the criteria of the American Diabetes Association.
Patients The present study consisted of 178 consecutive patients who underwent diagnostic coronary arteriography and a 75-g glucose tolerance test.
Results The level of plasma thioredoxin, a marker of oxidative stress was measured in every patient during the fasting state. The levels of plasma thioredoxin were significantly higher in the DM and IGT groups than the NGT group. Furthermore, we found that there was a positive association between thioredoxin levels and glycosylated hemoglobin (σ=0.225, p=0.018). In multivariate logistic regression analysis, glucose intolerance (DM or IGT) was only independently associated with the high levels of thioredoxin. The levels of plasma thioredoxin were significantly higher in the CAD group compared to the non-CAD group. In multivariate logistic regression analysis, high levels of thioredoxin, male, age and hypertension were independently associated with the presence of CAD.
Conclusion Glucose intolerance was associated with the high levels of thioredoxin. High levels of thioredoxin were related to the presence of CAD. The measurement of thioredoxin as the marker of oxidative stress may be useful for monitoring the development of the cardiovascular diseases.

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© 2005 by The Japanese Society of Internal Medicine
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