Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Small Hepatocellular Carcinoma Associated with Wilson’s Disease
Teru KUMAGINorio HORIIKEMasanori ABEKiyotaka KUROSEHideto IUCHIToshikazu MASUMOTOKoji JOKOSK. MD. Fazle AKBARKojiro MICHITAKAMorikazu ONJI
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JOURNAL OPEN ACCESS

2005 Volume 44 Issue 5 Pages 439-443

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Abstract

We report a 66-year-old male patient with hepatocellular carcinoma (HCC) associated with Wilson’s disease. The patient presented with unresolving abnormal liver function test, decreased serum ceruloplasmin levels and increased 24-hour urine copper excretion. Liver biopsy specimen revealed the presence of increased levels of copper and features suggestive of Wilson’s disease. Abdominal imaging showed the existence of a small HCC. Three years after chemoembolization and microwave coagulation therapy for HCC, he died of hepatic failure, which apparently resulted from chemoembolization. Patients with Wilson’s disease should be screened for HCC. We should elude therapies such as chemoembolization in these patients.

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© 2005 by The Japanese Society of Internal Medicine
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