Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Successful Treatment of Progressive Henoch-Schönlein Purpura Nephritis with Tonsillectomy and Steroid Pulse Therapy
Hitoshi SUGIYAMANaomi WATANABETetsuya ONODAYoko KIKUMOTOMiki YAMAMOTOManabu MAETANobuya OHARAYohei MAESHIMAYasushi YAMASAKIHirofumi MAKINO
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JOURNALS OPEN ACCESS

2005 Volume 44 Issue 6 Pages 611-615

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Abstract

Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by a leukocytoclastic vasculitis involving small vessels with the deposition of IgA immune complexes. The renal involvement is the major cause of morbidity and mortality in patients with HSP. We report here an adult patient with HSP nephritis (HSPN) accompanied by persistent proteinuria and progressive renal dysfunction despite conventional therapy. The patient was successfully treated with tonsillectomy followed by intravenous pulse methylprednisolone and oral prednisone. The combination therapy resulted in a significant decrease in proteinuria, improvement of renal function and the disappearance of microhematuria. The patient finally reached a stage of clinical remission.

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© 2005 by The Japanese Society of Internal Medicine
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