Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Amiodarone Pulmonary Toxicity: A Patient with Three Recurrences of Pulmonary Toxicity and Consideration of the Probable Risk for Relapse
Kaori OkayasuYuichiro TakedaJun KojimaAtsuto YoshizawaNobuyuki KobayashiHaruhito SugiyamaKoichiro Kudo
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JOURNAL OPEN ACCESS

2006 Volume 45 Issue 22 Pages 1303-1307

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Abstract

A 44-year-old man was treated with amiodarone for dilated cardiomyopathy. After 53 months, he developed amiodarone-induced interstitial pneumonia. Amiodarone treatment was terminated, and the patient was given corticosteroids. These treatments were effective. However, pneumonitis recurred whenever prednisolone was reduced to less than 5 mg per day. Considering the patient's background characteristics, we considered his body mass index (BMI, kg/m2) and found his to be high. When four additional patients with amiodarone pulmonary toxicity were reviewed at our institute, a correlation between BMI and the duration of shadow disappearance was found (R2=0.8695). Because amiodarone is lipophilic, the patient's high BMI might have influenced the repeated appearance of pulmonary toxicity.

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© 2006 by The Japanese Society of Internal Medicine
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