Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Polyarteritis Nodosa in Association with Subarachnoid Hemorrhage
Masahiro OomuraTakemori YamawakiHiroaki NaritomiTadashi TeraiKoji Shigeno
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JOURNAL OPEN ACCESS

2006 Volume 45 Issue 9 Pages 655-658

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Abstract

We report a 65-year-old man with classic polyarteritis nodosa (PAN) who developed subarachnoid hemorrhage. Polyarteritis nodosa was strongly suspected, however, the biopsy specimens of kidney and sural nerve showed no findings of vasculitis and the serum titer of antimyeloperoxidase-antineutrophil cytoplasmic autoantibody (MPO-ANCA) was negative. Cranial magnetic resonance angiography showed no findings of aneurysms. He developed subarachnoid hemorrhage (SAH) during the course and died. Autopsy confirmed fibrinoid necrosis in the medium-sized artery of multiple organs. To our knowledge, this is the first report of a case of classic PAN accompanied by SAH in which MPO-ANCA proved negative.

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© 2006 by The Japanese Society of Internal Medicine
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