Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Idiopathic Hypereosinophilic Syndrome Presenting Acute Abdomen
Makoto KobayashiNaoki KomatsuYoshio KuwayamaKentaro BandobashiTetsuya KubotaYoshiki UemuraHirokuni Taguchi
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JOURNAL OPEN ACCESS

2007 Volume 46 Issue 10 Pages 675-678

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Abstract

We describe a 27-year-old man with hypereosinophilc syndrome (HES) presenting acute abdomen due to acute thrombosis of the mesenteric artery, who had a past history of eosinophilic pneumonia followed by multiple arterial thromboses of the extremities. At the recurrence of eosinophilia, he was treated with high-dose corticosteroids. Immediately after the reduction of peripheral blood eosinophils, he suddenly developed perforation of the intestine due to acute thromboses of mesenteric arteries despite sustained anticoagulation therapy. Molecular analysis demonstrated that the FIP1L1-PDGFRA fusion gene was negative. Histopathology showed thrombi and eosinophilic inflammation of arteries. It is important to recognize that HES could be a cause of acute abdomen.

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© 2007 by The Japanese Society of Internal Medicine
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