Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Rapid-Onset Type 1 Diabetes Associated with Cytomegalovirus Infection and Islet Autoantibody Synthesis
Keiichiro OsameYoshihiko TakahashiHirofumi TakasawaShigeru WatanabeMiyako KishimotoKazuki YasudaYasushi KaburagiKoji NakanishiHiroshi KajioMitsuhiko Noda
Author information
JOURNALS OPEN ACCESS

2007 Volume 46 Issue 12 Pages 873-877

Details
Abstract

We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1*0901-DQA1*03-DQB1*0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.

Information related to the author
© 2007 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top