Two Cases of Acute Exacerbation of Interstitial Pneumonia Treated with Polymyxin B-immobilized Fiber Column Hemoperfusion Treatment

Satoshi Noma; Wataru Matsuyama; Hideo Mitsuyama; Takayuki Suetsugu; Yoshimizu Koreeda; Keiko Mizuno; Ikkou Higashimoto; Yasuyuki Kakihana; Teruto Hashiguchi; Ikuro Maruyama; Mitsuhiro Osame; Kimiyoshi Arimura

doi:10.2169/internalmedicine.46.0117

CASE REPORTS

Two Cases of Acute Exacerbation of Interstitial Pneumonia Treated with Polymyxin B-immobilized Fiber Column Hemoperfusion Treatment

Satoshi Noma, Wataru Matsuyama, Hideo Mitsuyama, Takayuki Suetsugu, Yoshimizu Koreeda, Keiko Mizuno, Ikkou Higashimoto, Yasuyuki Kakihana, Teruto Hashiguchi, Ikuro Maruyama, Mitsuhiro Osame, Kimiyoshi Arimura

Author information

Satoshi Noma
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Wataru Matsuyama
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Hideo Mitsuyama
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Takayuki Suetsugu
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Yoshimizu Koreeda
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Keiko Mizuno
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Ikkou Higashimoto
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Yasuyuki Kakihana
Division of Intensive Care Medicine, Kagoshima University Hospital
Teruto Hashiguchi
Department of Laboratory and Vascular Medicine Cardiovascular and Respiratory Disorders Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Science
Ikuro Maruyama
Department of Laboratory and Vascular Medicine Cardiovascular and Respiratory Disorders Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Science
Mitsuhiro Osame
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital
Kimiyoshi Arimura
Division of Respiratory Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital

Keywords: bronchoalveolar lavage fluid cells, CD18+/CD11c, high mobility group box-1 (HMGB-1)

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 17 Pages 1447-1454

DOI https://doi.org/10.2169/internalmedicine.46.0117

Details

Abstract

The effect of polymixin B-immobilized fiber column (PMX) hemoperfusion treatment for acute exacerbation of interstitial pneumonia (IP) has been reported. Here, we report 2 cases of acute exacerbation of IP successfully treated with PMX hemoperfusion. One is a 55-year-old woman who was diagnosed as microscopic polyangiitis (MPA) with IP. The other is a 58-year-old man, diagnosed as having idiopathic pulmonary fibrosis. Both cases were treated with PMX hemoperfusion and other therapies. One died on day 44 and the other is still alive. The PMX hemoperfusion treatment decreased the serum levels of several cytokines and activated neutrophil percentage in bronchoalveolar lavage fluid.

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