Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
Severe Cerebral Calcification in a Case of LEOPARD Syndrome
Atsushi NiwaYutaka NaitoShigeki Kuzuhara
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JOURNALS OPEN ACCESS

2008 Volume 47 Issue 21 Pages 1925-1929

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Abstract

We report severe brain calcification in a case of LEOPARD syndrome that has not been reported in the literature. A 53-year-old Japanese man presented with generalized lentigines, arrhythmia, gonadal hypoplasia, endocrine abnormality, mental retardation and skeletal abnormalities, and was consequently diagnosed as LEOPARD syndrome. Brain computed tomography demonstrated surprisingly dense and symmetric calcifications in the cerebellar dentate nuclei, cerebral basal ganglia, thalamus, and cerebral white matter. It may be an incidental idiopathic calcification. Alternatively it may be a rare clinical manifestation of LEOPARD syndrome.

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© 2008 by The Japanese Society of Internal Medicine
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