Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Immunoproliferative Small Intestinal Disease with Protein Loss Complicated with Duodenal T Cell Lymphoma during Progression
Takeshi HaraHisashi TsurumiTomohiro KatoYasuyuki ImaoYasushi KojimaKeishi KojimaJun-ichi KitagawaNaoki KatsumuraHiroshi ArakiTsuyoshi TakamiHisataka Moriwaki
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JOURNALS OPEN ACCESS

2008 Volume 47 Issue 4 Pages 299-303

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Abstract

A 52-year-old man was admitted to our hospital in October 2001 with abdominal pain. Abdominal X-ray indicated a diagnosis of ileus. Histopathological and immunological examination resulted in a diagnosis of immunoproliferative small intestinal disease (IPSID). He was treated with THP-COP therapy (pirarubicin, cyclophosphamide, vincristine, and prednisolone), which resulted in complete remission. Outpatient follow-up revealed hypoalbuminemia in May 2003 and upper gastrointestinal endoscopy showed duodenal mucosal nodularity. He was diagnosed with relapsed IPSID and salvage chemotherapy was started. Follow-up endoscopy confirmed that the therapy was effective, but uncovered another duodenal mucosal nodularity. Immunohistochemical staining revealed T-cell lymphoma. Chemotherapy was discontinued and the patient died in December 2004.

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© 2008 by The Japanese Society of Internal Medicine
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