Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
Severe Legionnaires' Disease Successfully Treated Using a Combination of Fluoroquinolone, Erythromycin, Corticosteroid, and Sivelestat
Hiroshi KakeyaNaomi EharaKiyoyasu FukushimaMasafumi SekiKoichi IzumikawaYoshihiro YamamotoKatsunori YanagiharaAtsushi SaitoShigeru Kohno
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JOURNALS OPEN ACCESS

2008 Volume 47 Issue 8 Pages 773-777

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Abstract

The patient was a 67-year-old man with diabetes mellitus who had been to a hot spring spa a few days before his admission. The diagnosis of Legionella pneumonia was made using a urinary antigen assay. Intravenous pazufloxacin and oral clarithromycin were started. However, despite these treatments, he developed acute respiratory distress syndrome (ARDS). He was administered the combination of intravenous pazufloxacin and erythromycin, corticosteroid, and sivelestat for two weeks. Then he was successfully recovered. The outcome suggests that treatment with corticosteroid and sivelestat, in addition to a combination of appropriate anti-Legionella antibiotics, should be considered for patients with severe Legionella pneumonia with ARDS.

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© 2008 by The Japanese Society of Internal Medicine
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