Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Multiple Myeloma with a Variant Burkitt-type Translocation, t(2;8)(p12;q24), Associated with Hyperammonemia
Yasuhiro YamamotoYoshizumi KonoikeHirokazu NakamineShinobu NakamuraTakeshi MoriiHiroshi Kimura
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JOURNALS OPEN ACCESS

2009 Volume 48 Issue 14 Pages 1239-1242

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Abstract

We report an 82-year-old Japanese woman with multiple myeloma (MM). She developed disorientation due to hyperammonemia after melphalan and prednisolone therapy and abruptly died with a rapid clinical course. Karyotypic analysis of bone marrow showed complex abnormalities including a variant Burkitt-type translocation, t(2;8)(p12;q24), but the patient had IgG-λ type M-proteinemia. Although patients with MM associated with hyperammonemia have been sporadically reported and their prognosis is poor, specific chromosomal abnormalities in the lesion have not been well characterized. It is, therefore, important to accumulate such patients to find a possible relationship between hyperammonemia and chromosomal abnormalities.

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© 2009 by The Japanese Society of Internal Medicine
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