Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Severe Hypophosphatemic Osteomalacia with Fanconi Syndrome, Renal Tubular Acidosis, Vitamin D Deficiency and Primary Biliary Cirrhosis
Hironori BandoNaoko HashimotoYushi HirotaKazuhiko SakaguchiItoko HisaYoshifumi InoueYasuo ImanishiSusumu SeinoHiroshi Kaji
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JOURNALS OPEN ACCESS

2009 Volume 48 Issue 5 Pages 353-358

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Abstract

A 49-year-old woman was admitted to our hospital for back pain with marked thoracic and extremity deformities leading to bed-rest for three years. She was diagnosed with hypophosphatemic osteomalacia based on her symptoms, X-ray and bone scintigram, high serum alkaline phosphatase level, and low serum levels of both phosphorus and 1,25 dihydroxyvitamin D3 with inhibition of phosphorus reabsorption. Fanconi syndrome with renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis were related to the pathogenesis of osteomalacia in this case. Several causal diseases may be concomitantly responsible for acceleration of the severity of osteomalacia in this patient.

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© 2009 by The Japanese Society of Internal Medicine
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