Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
IgG4-related Chronic Tubulointerstitial Nephritis without Autoimmune Pancreatitis and the Time Course of Renal Function
Yutaka TsubataFumihiro AkiyamaTakeshi OyaJunya AjiroTakako SaekiShinichi NishiIchiei Narita
Author information
JOURNALS OPEN ACCESS

2010 Volume 49 Issue 15 Pages 1593-1598

Details
Abstract

We report an elderly man with chronic tubulointerstitial nephritis (TIN) showing a high serum immunoglobulin G4 (IgG4) concentration. His serum creatinine (Scr) level had gradually increased from 0.9 mg/dL to 5.6 mg/dL over 18 months. Renal biopsy showed marked IgG4-positive plasma cell infiltration in the interstitium without glomerular abnormalities and IgG4-related TIN was diagnosed. Oral prednisolone reduced his Scr and IgG4 levels immediately. The present case indicates that IgG4-related TIN can not only progress rapidly but also chronically over a long period without significant urinary abnormalities, and we should consider hidden IgG4-related TIN in cases of chronic renal insufficiency.

Information related to the author
© 2010 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top