Internal Medicine
CASE REPORTS
Primary Bilateral Adrenal Diffuse Large B-cell Lymphoma Demonstrating Adrenal Failure
Kazuhiko HoriguchiKoshi HashimotoMasayuki HashizumeTakashige MasuoMariko SutoJun OkajoHiroshi HandaYoriaki KanekoHideaki YokooAtsushi SasakiShuichi OkadaMasanobu YamadaNorifumi TsukamotoYoshihisa NojimaYoichi NakazatoMasatomo Mori
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JOURNALS OPEN ACCESS

Volume 49 (2010) Issue 20 Pages 2241-2246

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Abstract

Primary adrenal lymphoma (PAL) is extremely rare although involvement of malignant lymphoma into adrenals is common. We report a case of a 58-year-old man with bilateral PAL who demonstrated adrenal insufficiency. Primary large B-cell lymphoma was proven by a computed tomography-guided needle biopsy of the adrenal tumor. Although a complete remission was once achieved by combination chemotherapy plus rituximab, a recurrence occurred with brain metastasis leading to his death. We concluded that PAL should be considered as a possible cause of bilateral adrenal incidentalomas with progressive adrenal insufficiency.

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© 2010 by The Japanese Society of Internal Medicine
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