Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Autoimmune Hemolytic Anemia Accompanied by Reactivation of an Epstein-Barr Virus Infection with Suppressed CTL Response to EBV-infected Cells in an Elderly Man
Ayako AraiKen-Ichi ImadomeShigeyoshi FujiwaraOsamu Miura
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JOURNALS OPEN ACCESS

2010 Volume 49 Issue 4 Pages 325-329

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Abstract

An 88-year-old man with autoimmune hemolytic anemia (AIHA) who had been treated with low dose prednisolone developed a sudden worsening of his anemia accompanied by reactivation of Epstein-Barr virus (EBV). We established EBV-infected spontaneous lymphoblastoid cell lines (LCL), performed an enzyme-linked immunosorbent spot assay, and confirmed a significantly suppressed EBV-specific cytotoxic T-cell (CTL) response to the LCL. EBV reactivation might have been brought about by suppressed CTL activity which could have been due to low dose PSL administration or aging. Since the EBV-DNA titer decreased as AIHA improved, we concluded that EBV might have played a role in the development of anemia.

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© 2010 by The Japanese Society of Internal Medicine
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