Type B Insulin Resistance Complicated with Systemic Lupus Erythematosus

Shin-ya Kawashiri; Atsushi Kawakami; Keita Fujikawa; Naoki Iwamoto; Toshiyuki Aramaki; Mami Tamai; Hideki Nakamura; Tomoki Origuchi; Hiroaki Ida; Katsumi Eguchi

doi:10.2169/internalmedicine.49.2746

CASE REPORTS

Type B Insulin Resistance Complicated with Systemic Lupus Erythematosus

Shin-ya Kawashiri, Atsushi Kawakami, Keita Fujikawa, Naoki Iwamoto, Toshiyuki Aramaki, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Hiroaki Ida, Katsumi Eguchi

Author information

Shin-ya Kawashiri
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Atsushi Kawakami
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Keita Fujikawa
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Naoki Iwamoto
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Toshiyuki Aramaki
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Mami Tamai
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Hideki Nakamura
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Tomoki Origuchi
Nagasaki University School of Health Sciences, Nagasaki University
Hiroaki Ida
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University
Katsumi Eguchi
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University

Keywords: type B insulin resistance, anti-insulin receptor antibody, systemic lupus erythematosus

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 5 Pages 487-490

DOI https://doi.org/10.2169/internalmedicine.49.2746

Details

Abstract

Type B insulin resistance is characterized by the appearance of autoantibodies to the insulin receptor. We present a 59-year-old Japanese man with type B insulin resistance complicated with systemic lupus erythematosus (SLE). A high titer of anti-insulin receptor autoantibodies was revealed when SLE was defined as active disease. Intravenous boluses of cyclophosphamide (IVCY) with oral prednisolone and cyclosporin A induced remission of SLE, and a subsequent disappearance of anti-insulin receptor autoantibodies, followed by a recovery of glucose intolerance. This is a rare and important case report showing a clear correlation between anti-insulin receptor autoantibodies of type B insulin resistance and SLE disease activity.

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