Hepatocellular Carcinoma in a Case of Wilson's Disease Treated with Radiofrequency Ablation Therapy

Shuntaro Ikegawa; Atsushi Hiraoka; Yukou Shimizu; Satoshi Hidaka; Nayu Tazuya; Misa Ichiryu; Hiromasa Nakahara; Atsushi Tanabe; Tetsuya Tanihira; Aki Hasebe; Yasunao Miyamoto; Tomoyuki Ninomiya; Masashi Hirooka; Teru Kumagi; Masanori Abe; Yoichi Hiasa; Morikazu Onji; Kojiro Michitaka

doi:10.2169/internalmedicine.50.5203

CASE REPORTS

Hepatocellular Carcinoma in a Case of Wilson's Disease Treated with Radiofrequency Ablation Therapy

Shuntaro Ikegawa, Atsushi Hiraoka, Yukou Shimizu, Satoshi Hidaka, Nayu Tazuya, Misa Ichiryu, Hiromasa Nakahara, Atsushi Tanabe, Tetsuya Tanihira, Aki Hasebe, Yasunao Miyamoto, Tomoyuki Ninomiya, Masashi Hirooka, Teru Kumagi, Masanori Abe, Yoichi Hiasa, Morikazu Onji, Kojiro Michitaka

Author information

Shuntaro Ikegawa
Ehime Prefectural Central Hospital, Japan
Atsushi Hiraoka
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Yukou Shimizu
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Satoshi Hidaka
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Nayu Tazuya
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Misa Ichiryu
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Hiromasa Nakahara
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Atsushi Tanabe
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Tetsuya Tanihira
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Aki Hasebe
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Yasunao Miyamoto
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Tomoyuki Ninomiya
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan
Masashi Hirooka
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Teru Kumagi
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Masanori Abe
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Yoichi Hiasa
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Morikazu Onji
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Japan
Kojiro Michitaka
Gastroenterology Center, Ehime Prefectural Central Hospital, Japan

Keywords: hepatocellular carcioma, Wilson's disease

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 13 Pages 1433-1437

DOI https://doi.org/10.2169/internalmedicine.50.5203

Details

Abstract

A 37-year-old Japanese man was diagnosed with liver cirrhosis due to Wilson's disease in 2001 and treated with D-penicillamine. Thereafter, he was admitted to our hospital for further examination of a space occupying lesion in the liver. The patient was diagnosed with hepatocellular carcinoma (HCC) (7th segment, 2.5 cm in diameter) in May 2010 and treated with radiofrequency ablation therapy. Biopsy findings from a non-cancerous area revealed a fatty liver, though cirrhotic nodules were not found. Long-term treatment for Wilson's disease may improve hepatic fibrosis, and careful screening for HCC by abdominal imaging is needed in such cases.

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