Mantle Cell Lymphoma Mainly Involving Thoracic Lesions: Two Case Reports

Makoto Kosaka; Tomonobu Koizumi; Toshirou Fukushima; Yousuke Wada; Toshihiko Agatsuma; Toshiki Yokoyama; Shintorou Kanda; Keishi Kubo; Hisashi Shimojo; Shirou Horie; Naoko Asano

doi:10.2169/internalmedicine.50.5335

CASE REPORTS

Mantle Cell Lymphoma Mainly Involving Thoracic Lesions: Two Case Reports

Makoto Kosaka, Tomonobu Koizumi, Toshirou Fukushima, Yousuke Wada, Toshihiko Agatsuma, Toshiki Yokoyama, Shintorou Kanda, Keishi Kubo, Hisashi Shimojo, Shirou Horie, Naoko Asano

Author information

Makoto Kosaka
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Tomonobu Koizumi
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Toshirou Fukushima
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Yousuke Wada
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Toshihiko Agatsuma
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Toshiki Yokoyama
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Shintorou Kanda
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Keishi Kubo
The First Department of Internal Medicine, Shinshu University School of Medicine, Japan
Hisashi Shimojo
Central Laboratory, Shinshu University School of Medicine, Japan
Shirou Horie
Internal Medicine, Okaya City Hospital, Japan
Naoko Asano
Department of Clinical Laboratory, Nagoya University Hospital, Japan

Keywords: hilar lymphadenopathy, R-CHOP, chemotherapy, non-Hodgkin lymphoma

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 14 Pages 1477-1481

DOI https://doi.org/10.2169/internalmedicine.50.5335

Details

Abstract

Most mantle cell lymphoma patients show remarkable disseminated disease at the initial diagnosis. We describe two cases of mantle cell lymphoma mainly involving thoracic lesions at the initial presentation of the disease. The clinical presentations were right hilar lymphadenopathy in one case and right pleural thickness in the other. The diagnosis of mantle cell lymphoma was confirmed by immunohistochemistry, including CD5, CD20, and cyclin D1, and the presence of t(11 ; 14)(q13 ; q32) by fluorescence in situ hybridization. These thoracic manifestations at the initial diagnosis should be taken into consideration for the clinical spectrum of mantle cell lymphoma.

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