Pramipexole Reduces the Prevalence of Fatigue in Patients with Parkinson's Disease

Akihiko Morita; Yasuyuki Okuma; Satoshi Kamei; Fumihito Yoshii; Toshimasa Yamamoto; Shiori Hashimoto; Hiroya Utsumi; Taku Hatano; Nobutaka Hattori; Miyuki Matsumura; Kazushi Takahashi; Shigeru Nogawa; Yuka Watanabe; Tomoyuki Miyamoto; Masayuki Miyamoto; Koichi Hirata

doi:10.2169/internalmedicine.50.5456

ORIGINAL ARTICLES

Pramipexole Reduces the Prevalence of Fatigue in Patients with Parkinson's Disease

Akihiko Morita, Yasuyuki Okuma, Satoshi Kamei, Fumihito Yoshii, Toshimasa Yamamoto, Shiori Hashimoto, Hiroya Utsumi, Taku Hatano, Nobutaka Hattori, Miyuki Matsumura, Kazushi Takahashi, Shigeru Nogawa, Yuka Watanabe, Tomoyuki Miyamoto, Masayuki Miyamoto, Koichi Hirata

Author information

Akihiko Morita
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Japan
Yasuyuki Okuma
Department of Neurology, Juntendo University Shizuoka Hospital, Japan
Satoshi Kamei
Division of Neurology, Department of Medicine, Nihon University School of Medicine, Japan
Fumihito Yoshii
Department of Neurology, Tokai University School of Medicine, Japan
Toshimasa Yamamoto
Department of Neurology, Faculty of Medicine, Saitama Medical University, Japan
Shiori Hashimoto
Department of Neurology, Tokyo Women's Medical University, Japan
Hiroya Utsumi
The Third Department of Internal Medicine, Division of Neurology, Tokyo Medical University, School of Medicine, Japan
Taku Hatano
Department of Neurology, Juntendo University School of Medicine, Japan
Nobutaka Hattori
Department of Neurology, Juntendo University School of Medicine, Japan
Miyuki Matsumura
Institute of Geriatrics, Tokyo Women's Medical University, Japan
Kazushi Takahashi
Department of Neurology, Keio University School of Medicine, Japan
Shigeru Nogawa
Department of Medicine, Tokyo Dental College Ichikawa General Hospital, Japan
Yuka Watanabe
Department of Neurology, Dokkyo Medical University, Japan
Tomoyuki Miyamoto
Department of Neurology, Dokkyo Medical University, Japan
Masayuki Miyamoto
Department of Neurology, Dokkyo Medical University, Japan
Koichi Hirata
Department of Neurology, Dokkyo Medical University, Japan

Keywords: Parkinson's disease, fatigue, Pramipexole

JOURNAL OPEN ACCESS

2011 Volume 50 Issue 19 Pages 2163-2168

DOI https://doi.org/10.2169/internalmedicine.50.5456

Details

Abstract

Objective The aim of this multicenter cross-sectional study was to assess the relation between fatigue in a large number of Japanese patients with Parkinson's disease (PD) and drugs taken to treat PD.
Method We used the 16-item Parkinson Fatigue Scale (PFS-16), which was designed to assess fatigue exclusively associated with PD. Multiple logistic regression analyses were used to assess the relation between antiparkinson drugs and fatigue in PD.
Results A total of 350 non-demented PD patients were enrolled. Fatigue (PFS score of ≥4) was revealed in 319 patients (91%). Pramipexole was administered to 24% of PD patients. Multiple logistic regression analysis revealed that the administration of Pramipexole was significantly related to low rates of fatigue in PD patients with Hoehn and Yahr stage <3 (p=0.011, odds ratio=5.23, 95% confidence interval; 1.47-18.63).
Conclusion The reduced fatigue in PD patients was observed in taking Pramipexole.

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