Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
False-Positive Human Immunodeficiency Virus Antibody Test and Autoimmune Hemolytic Anemia in a Patient with Angioimmunoblastic T-Cell Lymphoma
Seiji ShidaNaoto TakahashiNaohito FujishimaYoshihiro KameokaMiho NaraMasumi FujishimaHirobumi SaitohHiroyuki TagawaMakoto HirokawaRyo IchinohasamaKenichi Sawada
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JOURNALS OPEN ACCESS

2011 Volume 50 Issue 20 Pages 2383-2387

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Abstract

A 44-year-old woman was admitted with generalized lymphadenopathy, which was diagnosed as angioimmunoblastic T-cell lymphoma (AITL). The patient showed autoimmune hemolytic anemia (AIHA), polyclonal hypergammaglobulinemia and a high antinuclear antibody titer. Moreover, a human immunodeficiency virus (HIV)-1/2 screening test using the particle agglutination method was reactive. After chemotherapy for AITL, the AIHA was eliminated, and the false-positive HIV results were no longer detected. Autoimmunity associated with AITL is the likely cause of the cross-reaction with HIV and the AIHA. It is important to recognize that the cross-reaction with HIV can be a potential complication in AITL as well as AIHA.

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© 2011 by The Japanese Society of Internal Medicine
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