Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Culture-negative Brain Abscess with Streptococcus intermedius Infection with Diagnosis Established by Direct Nucleotide Sequence Analysis of the 16S Ribosomal RNA Gene
Naoko SaitoAyumi HidaYuri KoideTadasuke OokaYaeko IchikawaJun ShimizuAkitake MukasaHirofumi NakatomiShuji HatakeyamaTetsuya HayashiShoji Tsuji
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JOURNALS OPEN ACCESS

2012 Volume 51 Issue 2 Pages 211-216

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Abstract

A 70-year-old woman developed a headache for a month followed by right upper limb weakness. CT scan and MRI showed multiple ring-enhancing lesions. An intracerebral aspiration of an abscess was performed, but culture results were negative. The nucleotide sequence analysis of the 16S rRNA gene from the specimens identified Streptococcus intermedius. Given this result, S. intermedius was cultured by enrichment culture, and its sensitivities to antibiotics were determined. The patient exhibited complete remission. Thus, 16S rRNA gene analysis was highly useful not only for pathogen identification with negative culture results but also for the appropriate selection of antibiotics.

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© 2012 by The Japanese Society of Internal Medicine
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