Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas Responsive to Combination Therapy with Gemcitabine and S-1
Mitsuyoshi YamamotoKoichiro MiyagawaMasaaki HiuraMasashi TaguchiYasuyuki KiharaShintaro AbeShohei ShimajiriMasaru Harada
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JOURNAL OPEN ACCESS

2012 Volume 51 Issue 7 Pages 727-732

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Abstract

Poorly differentiated neuroendocrine carcinoma is a very rare malignancy, but it is characterized by agressive histological features and a poor clinical prognosis. We report a 42-year-old man who had poorly differentiated neuroendocrine carcinoma of the pancreas with multiple liver metastases. We administrated combined chemotherapy with S-1 and gemcitabine. This treatment was efficacious and well tolerated, and then this patient obtained objective partial response for 7 months and survived for 13 months after the diagnosis. This case suggests that S-1 and gemcitabine combination produce beneficial responses for patients with this disease.

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© 2012 by The Japanese Society of Internal Medicine
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