Autoimmune Pancreatitis with Histologically Proven Lymphoplasmacytic Sclerosing Pancreatitis with Granulocytic Epithelial Lesions

Tsukasa Ikeura; Makoto Takaoka; Kazushige Uchida; Masaaki Shimatani; Hideaki Miyoshi; Takeo Kusuda; Akiko Kurishima; Yuri Fukui; Kimi Sumimoto; Sohei Satoi; Chisato Ohe; Yoshiko Uemura; A-Hon Kwon; Kazuichi Okazaki

doi:10.2169/internalmedicine.51.6859

CASE REPORTS

Autoimmune Pancreatitis with Histologically Proven Lymphoplasmacytic Sclerosing Pancreatitis with Granulocytic Epithelial Lesions

Tsukasa Ikeura, Makoto Takaoka, Kazushige Uchida, Masaaki Shimatani, Hideaki Miyoshi, Takeo Kusuda, Akiko Kurishima, Yuri Fukui, Kimi Sumimoto, Sohei Satoi, Chisato Ohe, Yoshiko Uemura, A-Hon Kwon, Kazuichi Okazaki

Author information

Tsukasa Ikeura
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Makoto Takaoka
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Kazushige Uchida
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Masaaki Shimatani
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Hideaki Miyoshi
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Takeo Kusuda
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Akiko Kurishima
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Yuri Fukui
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Kimi Sumimoto
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan
Sohei Satoi
Department of Surgery, Kansai Medical University, Japan
Chisato Ohe
Department of Pathology, Kansai Medical University, Japan
Yoshiko Uemura
Department of Pathology, Kansai Medical University, Japan
A-Hon Kwon
Department of Surgery, Kansai Medical University, Japan
Kazuichi Okazaki
The Third Department of Internal Medicine, Division of Gastroenterology and Hepatology, Kansai Medical University, Japan

Keywords: autoimmune pancreatitis (AIP), lymphoplasmacytic sclerosing pancreatitis (LPSP), idiopathic duct-centric pancreatitis (IDCP), granulocytic epithelial lesion (GEL), IgG4

JOURNAL OPEN ACCESS

2012 Volume 51 Issue 7 Pages 733-737

DOI https://doi.org/10.2169/internalmedicine.51.6859

Details

Abstract

Recent histological and clinical studies have suggested the existence of 2 distinct types of autoimmune pancreatitis (AIP): type 1 AIP related to IgG4, exhibiting lymphoplasmacytic sclerosing pancreatitis (LPSP), and type 2 AIP related to granulocyte epithelial lesions (GELs), exhibiting idiopathic duct-centric chronic pancreatitis (IDCP). We herein present a case of type 1 AIP with histologically proven LPSP with GELs. This patient had neither serum IgG4 elevation nor MPD narrowing. In this case, the clinically and histologically atypical findings for type 1 AIP are intriguing.

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