Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Infective Endocarditis Caused by Enterococcus faecalis treated with Continuous Infusion of Ampicillin without Adjunctive Aminoglycosides
Taku OgawaMasatoshi SatoShinsuke YonekawaChiyo NakagawaKenji UnoKei KasaharaKoichi MaedaMitsuru KonishiKeiichi Mikasa
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JOURNAL OPEN ACCESS

2013 Volume 52 Issue 10 Pages 1131-1135

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Abstract

Aminoglycosides are useful antimicrobial agents for treating infective endocarditis; however, they occasionally cause troublesome side effects, such as nephrotoxicity and ototoxicity. We herein report a case of infective endocarditis caused by Enterococcus faecalis that was treated successfully with continuous infusion of ampicillin without adjunctive aminoglycosides. The serum ampicillin concentrations were higher than the minimal inhibitory concentration for the target strain. Although the use of ampicillin monotherapy is currently avoided because double β-lactam therapy is reportedly more effective, continuous penicillin administration remains an effective therapeutic choice for treating infective endocarditis.

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© 2013 by The Japanese Society of Internal Medicine
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