Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Talc Pleurodesis for the Management of Malignant Pleural Effusions in Japan
Takeo InoueAtsuko IshidaMiho NakamuraHiroki NishineMasamichi MineshitaTeruomi Miyazawa
Author information

2013 Volume 52 Issue 11 Pages 1173-1176


Objective Malignant pleural effusions are commonly treated with tube drainage followed by chemical pleurodesis to maintain the patient's quality of life. While talc is now accepted to be a worldwide gold-standard sclerosing agent for treating malignant pleural effusion, it is not yet approved in Japan. Instead, many patients are administered OK-432 for pleurodesis, which carries the risk of complications such as high-grade fever, chest pain, anaphylactic shock, interstitial pneumonia and acute renal failure. To assess the efficacy and safety of talc as a sclerosing agent in the management of malignant pleural effusions in Japanese patients.
Methods Pleurodesis was performed using 4 g of sterile talc with thoracoscopic talc poudrage or the administration of talc slurry via a chest tube in patients with malignant pleural effusions.
Results A total of 57 patients were included. The success rate of pleurodesis assessed on chest radiography at 30, 90 and 180 days was 90.6%, 80.9% and 76.1%, respectively. Complications occurring after talc pleurodesis included fever in 10.5% of the patients and chest pain in 14.0% of the patients. No major complications were reported.
Conclusion Talc pleurodesis is an effective and safe treatment for the management of malignant pleural effusion in Japanese patients.

Information related to the author
© 2013 by The Japanese Society of Internal Medicine
Previous article Next article