Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Pulmonary Tumor Thrombotic Microangiopathy with Circulatory Failure Treated with Imatinib
Aiko OgawaIchiro YamadoriOsamu MatsubaraHiromi Matsubara
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JOURNALS OPEN ACCESS

2013 Volume 52 Issue 17 Pages 1927-1930

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Abstract

Pulmonary tumor thrombotic microangiopathy is a lethal, yet difficult to diagnose, complication of gastrointestinal carcinoma. Even if properly diagnosed, there is no treatment, especially after a circulatory collapse. We herein report a case of pulmonary tumor thrombotic microangiopathy with circulatory failure due to pulmonary hypertension. The patient was temporarily successfully treated with imatinib, an inhibitor of the platelet-derived growth factor receptor. Pulmonary hypertension was dramatically ameliorated and the patient was able to be weaned from percutaneous cardiopulmonary support within 20 days of treatment. Imatinib may be effective for ameliorating pulmonary hypertension that is caused by pulmonary tumor thrombotic microangiopathy.

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© 2013 by The Japanese Society of Internal Medicine
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