Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
Successful Treatment with a Combination of Electrocautery Using Wire Snares and Gefitinib in Patients with EGFR-mutant Lung Cancer and Central Airway Obstruction
Tomoyuki ArayaYoshiki DemuraKazuo KasaharaHiroki MatsuokaMasaru NishitsujiKoichi Nishi
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JOURNALS OPEN ACCESS

2013 Volume 52 Issue 20 Pages 2331-2335

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Abstract

One-third of lung cancer patients present with life-threatening central airway obstruction (CAO). Two elderly patients were referred to our institution with symptoms caused by CAO. In each case, thoracic computed tomography and a bronchoscopic examination revealed a tumor obstructing the central airway. The tumors were resected endoscopically, and the patients' respiratory and performance status remarkably improved. Both patients were diagnosed with an advanced stage of lung adenocarcinoma harboring epidermal growth factor receptor (EGFR) mutations. They received gefitinib monotherapy, with partial responses sustained for more than 12 months. Combination therapy with endoscopic tumor resection and gefitinib is beneficial in patients with EGFR-mutant lung cancer and CAO.

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© 2013 by The Japanese Society of Internal Medicine
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