Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
Acute Myeloid Leukemia Concurrent with Spinal Epidural Extramedullary Myeloid Sarcoma Accompanied by a High CD25 Expression and the FLT3-ITD Mutation
Yusuke IsshikiChikako OhwadaEmi TogasakiRyoh ShimizuNagisa HasegawaAtsuko YamazakiYasumasa SugitaTakeharu KawaguchiShokichi TsukamotoShio SakaiYusuke TakedaMasahiro TakeuchiEmiko SakaidaNaomi ShimizuSatoshi OtaKoutaro YokoteTohru IsekiChiaki Nakaseko
Author information
JOURNALS OPEN ACCESS

2014 Volume 53 Issue 11 Pages 1159-1164

Details
Abstract

Myeloid sarcoma (MS) is an extramedullary myeloid tumor that sometimes presents with antedating systemic leukemia, leading physicians to the misdiagnosis of lymphoma. CD25 is expressed in 13% of patients with acute myeloid leukemia (AML), and its expression is associated with FLT3-ITD mutations, an elevated serum soluble interleukin 2 receptor (sIL-2R) level and a lower survival rate. However, there are no reports concerning the relationship between MS and the CD25 expression. We herein report a case of AML accompanied by thoracic epidural MS with a high CD25 expression, the FLT3-ITD mutation and an extremely elevated serum sIL-2R level in a 59-year-old man who presented with paraplegia.

Information related to the author
© 2014 by The Japanese Society of Internal Medicine
Previous article Next article
feedback
Top