Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Hepatosplenic Gamma-delta T-cell Lymphoma Associated with Epstein-Barr Virus
Seiji TsunematsuMitsuteru NatsuizakaHiromi FujitaNoriyuki OtsukaKatsumi TerashitaFumiyuki SatoTomoe KobayashiMasato NakaiYoko TsukudaHiromasa HorimotoTakuya ShoGoki SudaMitsuru NakanishiSatoshi HashinoMakoto ChumaNaoya Sakamoto
ジャーナル オープンアクセス

2014 年 53 巻 18 号 p. 2079-2082


Hepatosplenic gamma-delta T-cell lymphoma (HSTCL) is a rare, aggressive subset of peripheral T-cell lymphoma. It has been reported that Epstein-Barr virus (EBV) infection can cause HSTCL; however, such cases are extremely rare, with only a few cases having been reported to date. We herein report an autopsy case of HSTCL associated with EBV infection. The presence of EBV infection was confirmed in serum EBV DNA and on in-situ hybridization, and cytotoxic molecules, such as granzyme B, perforin and T-cell intracytoplasmic antigen (TIA)-1, were all positive in lymphoma cells. These findings indicate that stimulation of persistent EBV infection may have caused HSTCL in this patient.

© 2014 by The Japanese Society of Internal Medicine
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