Acute Kidney Injury in a Patient with Polyarteritis Nodosa and Multiple Myeloma

Kazuhiro Yokota; Tsutomu Inoue; Yuji Akiyama; Hiroshi Kajiyama; Yu Funakubo Asanuma; Eiichi Arai; Hiromichi Suzuki; Toshihide Mimura

doi:10.2169/internalmedicine.53.1120

CASE REPORTS

Acute Kidney Injury in a Patient with Polyarteritis Nodosa and Multiple Myeloma

Kazuhiro Yokota, Tsutomu Inoue, Yuji Akiyama, Hiroshi Kajiyama, Yu Funakubo Asanuma, Eiichi Arai, Hiromichi Suzuki, Toshihide Mimura

Author information

Kazuhiro Yokota
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Tsutomu Inoue
Department of Nephrology, Saitama Medical University, Japan
Yuji Akiyama
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Hiroshi Kajiyama
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Yu Funakubo Asanuma
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan
Eiichi Arai
Department of Pathology, Saitama Medical University, Japan
Hiromichi Suzuki
Department of Nephrology, Saitama Medical University, Japan
Toshihide Mimura
Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Japan

Keywords: acute kidney injury, polyarteritis nodosa, multiple myeloma, double filtration plasmapheresis

JOURNAL OPEN ACCESS

2014 Volume 53 Issue 3 Pages 263-267

DOI https://doi.org/10.2169/internalmedicine.53.1120

Details

Abstract

We herein report the case of a Japanese man with polyarteritis nodosa (PAN) accompanied by multiple myeloma (MM). The patient was diagnosed with PAN. Concurrently, IgG kappa paraprotein was detected, and bone marrow changes indicative of MM were observed. Prednisolone (PSL) administered at a dose of 30 mg/day was initiated; however, the serum creatinine level increased. In spite of increasing the dose of PSL to 45 mg/day and initiating treatment with double filtration plasmapheresis, the patient's renal dysfunction continued to progress and haemodialysis was introduced. He died from pneumonia 12 months after admission. We conclude that renal failure is an important risk factor in the prognosis of PAN accompanied by MM.

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