Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
HIV-negative Primary Bone Marrow Hodgkin Lymphoma Manifesting with a High Fever Associated with Hemophagocytosis as the Initial Symptom: A Case Report and Review of the Previous Literature
Yasuyoshi MoritaMasakatsu EmotoKentaro SerizawaShinya RaiChikara HiraseYoshitaka KanaiYasuyo OhyamaToshihiko ShigaHirokazu TanakaJunichi MiyatakeYoichi TatsumiTakashi AshidaMasatomo KimuraMasafumi ItoItaru Matsumura
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2015 Volume 54 Issue 11 Pages 1393-1396


A 68-year-old man was referred to our hospital due to a high fever and pancytopenia. Neither tumors nor infectious lesions were detected. Hemophagocytosis was observed on the bone marrow (BM) smear, although without abnormal cells. Prednisolone therapy was ineffective for the patient's high fever. Later on, we obtained the results of a BM biopsy indicating the presence of infiltration of atypical Reed-Sternberg cells, leading to a diagnosis of HIV-negative primary bone marrow Hodgkin lymphoma (PBMHL). However, the patient died of multiple organ failure before receiving chemotherapy. As the clinical course of PBMHL is rapid, physicians must keep in mind its possibility in similar cases.

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© 2015 by The Japanese Society of Internal Medicine
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