Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Autoimmune Hemorrhaphilia Resulting from Autoantibody against the A Subunit of Factor XIII
Emi UchidaKen WatanabeReina AraiMasahide YamamotoMasayoshi SouriTsukasa OsakiAkitada IchinoseOsamu MiuraTakatoshi Koyama
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JOURNALS OPEN ACCESS

2015 Volume 54 Issue 18 Pages 2383-2387

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Abstract

A 65-year-old woman was admitted with acute intramuscular hemorrhage of the left gluteus medius and piriformis muscles and associated anemia. Blood tests showed low plasma factor XIII (FXIII) antigen and activity. A cross-mixing test revealed a concave "inhibitor" pattern and anti-FXIII-A subunit antibody was detected. The patient was diagnosed with autoimmune hemorrhaphilia resulting from anti-FXIII antibody. The bleeding has not recurred since the initiation of treatment with oral immunosuppressive agents. Although hemorrhagic acquired FXIII deficiency is a rare disorder, prompt recognition of the underlying mechanism can save lives.

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© 2015 by The Japanese Society of Internal Medicine
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