Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
A Rare Case of Pleomorphic Carcinoma of the Lung Harboring an Anaplastic Lymphoma Kinase (ALK) Rearrangement
Takayuki ShiroyamaAyako TanakaMotohiro TamiyaMasanari HamaguchiAkio OsaSawa TakeokaEriko TaniYuichiro AzumaNaoko MorishitaHidekazu SuzukiNorio OkamotoKenji KimuraYoshihisa KadotaKunimitsu KawaharaTomonori HirashimaIchiro Kawase
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JOURNALS OPEN ACCESS

2015 Volume 54 Issue 21 Pages 2741-2743

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Abstract

Molecular testing for anomalies, such as epidermal growth factor receptor mutations and anaplastic lymphoma kinase (ALK) rearrangement, is part of the current standard of care for non-small cell lung cancer, particularly adenocarcinoma. ALK rearrangement occurs most frequently in adenocarcinoma cells and rarely in non-adenocarcinoma cells. We herein report a rare case of pleomorphic lung carcinoma with ALK rearrangement in both its adenocarcinoma and spindle cell components. This case suggests the possibility of ALK rearrangement in pleomorphic carcinoma.

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© 2015 by The Japanese Society of Internal Medicine
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