Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Successful Engraftment and Durable Graft-versus-host Disease Control with Haploidentical Peripheral Blood and a Short-term Conditioning Regimen for Primary Graft Failure
Takayoshi TachibanaEri YamamotoRika KawasakiHideyuki KoharazawaDaisuke IshibashiYuki NakajimaMasatsugu TanakaKenji MatsumotoYoshiaki IshigatsuboShin Fujisawa
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JOURNALS OPEN ACCESS

2015 Volume 54 Issue 21 Pages 2749-2752

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Abstract

Primary graft failure occurred after cord blood transplantation for a patient with acute lymphoblastic leukemia. The second transplantation was performed using haploidentical peripheral blood. The conditioning regimen consisted of fludarabine (day -1; 30 mg/m2), cyclophosphamide (day -1; 2,000 mg/m2), and total body irradiation (day -1; 2 Gy). The immunosuppressants contained tacrolimus, prednisolone, and rabbit anti-thymocyte globulin (day -3 to -2; total dose: 3.75 mg/kg). The engraftment was confirmed on day 9. Both acute and chronic graft-versus-host disease were controllable. The present regimen appears to be suitable for immediate management, fast engraftment, and the durable control of complications.

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© 2015 by The Japanese Society of Internal Medicine
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