Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Neurosyphilis Is a Long-forgotten Disease but Still a Possible Etiology for Dementia
Hideharu HagiyaKentaro DeguchiKiyohiro KawadaFumio Otsuka
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JOURNALS OPEN ACCESS

2015 Volume 54 Issue 21 Pages 2769-2773

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Abstract

We herein report a heterosexual Japanese man in his forties who had been suffering from advanced dementia and personality change for 4 years. Positive results of a serological test for syphilis, Treponema pallidum hemagglutination assay, and fluorescent treponemal antibody-absorption test of both serum and cerebral spinal fluid led to the diagnosis of neurosyphilis. Jarisch-Herxheimer reaction was seen shortly after the first dose of penicillin was administered to the patient. His cognitive function did not recover after treatment. The incidence of syphilis has been reported to be increasing. Neurosyphilis should not be overlooked as an etiology for progressive dementia even in this post-antibiotic era.

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© 2015 by The Japanese Society of Internal Medicine
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