Multi-organ Involvement of Sweet's Syndrome: A Case Report and Literature Review

Bo Li; Zhongsen Ma; Xuesong Xu; Jinzhi Yin; Xiuli Wang; Jin Ren; Songyan Wang; Junling Yang; Tiangang Ma; Qinghua Zhang; Jinyan Yu; Bingdi Yan

doi:10.2169/internalmedicine.54.2755

CASE REPORTS

Multi-organ Involvement of Sweet's Syndrome: A Case Report and Literature Review

Bo Li, Zhongsen Ma, Xuesong Xu, Jinzhi Yin, Xiuli Wang, Jin Ren, Songyan Wang, Junling Yang, Tiangang Ma, Qinghua Zhang, Jinyan Yu, Bingdi Yan

Author information

Bo Li
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Department of Occupational Disease Prevention, Jilin Provincial Occupational Disease Prevention and Treatment, China
Zhongsen Ma
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Xuesong Xu
Chinese Japanese Union Hospital, Jilin University, China
Jinzhi Yin
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Xiuli Wang
Department of Hematology and Oncology, The Second Clinical Hospital, Jilin University, China
Jin Ren
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Songyan Wang
Department of Nephrology, Jilin Provincial People's Hospital, China
Junling Yang
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Tiangang Ma
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Qinghua Zhang
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Jinyan Yu
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China
Bingdi Yan
Department of Respiratory Medicine, The Second Clinical Hospital, Jilin University, China

Keywords: Sweet syndrome, neutrophils, lung, heart, skin, inflammation

JOURNAL OPEN ACCESS

2015 Volume 54 Issue 3 Pages 339-343

DOI https://doi.org/10.2169/internalmedicine.54.2755

Details

Abstract

The hallmark of Sweet's syndrome (SS) is the infiltration of mature neutrophils in the upper dermis. We herein report a case of SS with multi-organ involvement. A 32-year-old man presented with fever, anemia and dyspnea. He was given antibiotics, without any improvements. Later, a number of erythematous lesions appeared, accompanied by deteriorating respiratory and cardiovascular functions. A diagnosis of SS was confirmed on a skin biopsy, and the patient was given corticosteroids, the dose of which was reduced after one month. The organ function subsequently deteriorated, and he ultimately died of multi-organ failure. Early recognition of SS with multi-organ involvement is important in patients with SS.

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