Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease

Mineto Ota; Hideyuki Iwai; Kaori Imai; Mari Kamiya; Yoko Yoshihashi-Nakazato; Nobuyuki Miyasaka; Hitoshi Kohsaka

doi:10.2169/internalmedicine.55.5834

CASE REPORTS

Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease

Mineto Ota, Hideyuki Iwai, Kaori Imai, Mari Kamiya, Yoko Yoshihashi-Nakazato, Nobuyuki Miyasaka, Hitoshi Kohsaka

Author information

Mineto Ota
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan
Hideyuki Iwai
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan
Kaori Imai
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan
Department of Pharmacovigilance, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan
Mari Kamiya
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan
Yoko Yoshihashi-Nakazato
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan
Nobuyuki Miyasaka
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan
Hitoshi Kohsaka
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan

Keywords: acute tubulointerstitial nephritis, Crohn's disease, infliximab

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 10 Pages 1367-1370

DOI https://doi.org/10.2169/internalmedicine.55.5834

Details

Abstract

We report the findings of a 46-year-old man, who presented with fever and renal dysfunction while undergoing treatment for Crohn's disease with infliximab (IFX). Remittent fever and renal dysfunction with urinary casts developed and lasted for 3 weeks without deterioration of Crohn's disease. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After the discontinuation of IFX, his fever and renal abnormalities resolved. We herein report the first known case of ATIN associated with IFX.

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