Two Cases of Chronic Gastritis with non-Helicobacter pylori Helicobacter Infection

Satoka Shiratori; Katsuhiro Mabe; Shinji Yoshii; Yasunari Takakuwa; Masaaki Sato; Masahiko Nakamura; Takahiko Kudo; Mototsugu Kato; Masahiro Asaka; Naoya Sakamoto

doi:10.2169/internalmedicine.55.5891

CASE REPORTS

Two Cases of Chronic Gastritis with non-Helicobacter pylori Helicobacter Infection

Satoka Shiratori, Katsuhiro Mabe, Shinji Yoshii, Yasunari Takakuwa, Masaaki Sato, Masahiko Nakamura, Takahiko Kudo, Mototsugu Kato, Masahiro Asaka, Naoya Sakamoto

Author information

Satoka Shiratori
Department of Gastroenterology, SAPPORO MEDICAL CENTER NTT EC, Nippon Telegraph and Telephone East Corporation, Japan
Katsuhiro Mabe
Department of Cancer Preventive Medicine, Hokkaido University Graduate School of Medicine, Japan
Shinji Yoshii
Department of Gastroenterology, SAPPORO MEDICAL CENTER NTT EC, Nippon Telegraph and Telephone East Corporation, Japan
Yasunari Takakuwa
Department of Pathology, SAPPORO MEDICAL CENTER NTT EC, Nippon Telegraph and Telephone East Corporation, Japan
Masaaki Sato
Department of Pathology, SAPPORO MEDICAL CENTER NTT EC, Nippon Telegraph and Telephone East Corporation, Japan
Masahiko Nakamura
School of Pharmaceutical Sciences, Kitasato University, Japan
Takahiko Kudo
Department of Gastroenterology, Sapporo City General Hospital, Japan
Mototsugu Kato
Division of Endoscopy, Hokkaido University Hospital, Japan
Masahiro Asaka
Department of Cancer Preventive Medicine, Hokkaido University Graduate School of Medicine, Japan
Naoya Sakamoto
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan

Keywords: Helicobacter species, Helicobacter pylori, Helicobacter suis, non-Helicobacter pylori helicobacter, chronic gastritis

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 14 Pages 1865-1869

DOI https://doi.org/10.2169/internalmedicine.55.5891

Details

Abstract

Two men, 48 and 54 years of age, were referred for medical checkups without any particular symptoms. Upper gastrointestinal endoscopy showed a normal gastric body, but white marbled appearance in the lesser curvature of the gastric angle and antrum. Biopsy specimens revealed relatively long and tightly coiled organisms. The two patients were diagnosed as having non-Helicobacter pylori helicobacter (NHPH) infection according to the findings of pathological and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses. After triple therapy (amoxicillin, clarithromycin, and rabeprazole), endoscopy showed an improvement of the white marbled lesions and biopsy specimens showed no NHPH. The white marbled appearance limited to the gastric angle and antrum may be a potential characteristic finding of NHPH-infected gastritis.

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