Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Insulin Autoimmune Syndrome Accompanied by Multiple Myeloma
Harumi ItoTakafumi MiyakeKazuo NakashimaYuji ItoChisato TanahashiYasuko Uchigata
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JOURNAL OPEN ACCESS

2016 Volume 55 Issue 16 Pages 2219-2224

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Abstract

In 1981, a 48-year old man was diagnosed with insulin autoimmune syndrome. In 2005, he experienced a substantial increase in his monoclonal insulin antibody levels; in 2006 and 2007, serum monoclonal gammopathy and an 11% marrow plasmacyte ratio were confirmed. In 2012, asymptomatic multiple myeloma was diagnosed based on an increased γ-globulin fraction and serum M-protein (IgG) levels. The insulin antibody binding rate was 75.4% in 2005 and 78.8% in 2012. In 2012, he was hospitalized for ileus and died. Autopsy identified multiple myeloma and no endocrinological tumors in the pancreas.

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© 2016 by The Japanese Society of Internal Medicine
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