IgG4-related Disease with Bone Marrow Involvement

Akifumi Ichiki; Norisato Hashimoto; Tomoki Ueda; Shinichiro Hiraiwa; Takuma Tajiri; Naoya Nakamura; Kiyoshi Ando; Kenji Yokoyama

doi:10.2169/internalmedicine.55.6749

CASE REPORTS

IgG4-related Disease with Bone Marrow Involvement

Akifumi Ichiki, Norisato Hashimoto, Tomoki Ueda, Shinichiro Hiraiwa, Takuma Tajiri, Naoya Nakamura, Kiyoshi Ando, Kenji Yokoyama

Author information

Akifumi Ichiki
Department of Hematology/Oncology, Tokai University Hachioji Hospital, Japan
Department of Hematology/Oncology, Tokai University School of Medicine, Japan
Norisato Hashimoto
Department of Hematology/Oncology, Tokai University Hachioji Hospital, Japan
Tomoki Ueda
Department of Hematology/Oncology, Tokai University Hachioji Hospital, Japan
Shinichiro Hiraiwa
Department of Pathology, Tokai University Hachioji Hospital, Japan
Takuma Tajiri
Department of Pathology, Tokai University Hachioji Hospital, Japan
Naoya Nakamura
Department of Pathology, Tokai University School of Medicine, Japan
Kiyoshi Ando
Department of Hematology/Oncology, Tokai University School of Medicine, Japan
Kenji Yokoyama
Department of Hematology/Oncology, Tokai University Hachioji Hospital, Japan

Keywords: IgG4-related disease, bone marrow involvement, FDG-PET/CT

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 16 Pages 2295-2299

DOI https://doi.org/10.2169/internalmedicine.55.6749

Details

Abstract

A 61-year-old Japanese woman with anemia, submandibular gland swelling, and enlarged lymph nodes was diagnosed with IgG4-related disease (IgG4-RD) by lymph node biopsy. Bone marrow involvement of IgG4-RD was detected by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) and immunohistochemically proven by bone marrow biopsy in this patient. Anemia progressed gradually, and prednisolone treatment was initiated. Anemia and submandibular gland swelling improved soon after prednisolone treatment was initiated. We report a rare case of IgG4-RD involving the bone marrow. FDG-PET/CT and bone marrow biopsy were useful for diagnosis in this case.

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