Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Relapsed Pulmonary Cryptococcosis during Tumor Necrosis Factor α Inhibitor Treatment
Takahiro TakazonoToyomitsu SawaiMasato TashiroTomomi SaijoKazuko YamamotoYoshifumi ImamuraTaiga MiyazakiNaofumi SuyamaKoichi IzumikawaHiroshi KakeyaKatsunori YanagiharaHiroshi MukaeShigeru Kohno
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JOURNAL OPEN ACCESS

2016 Volume 55 Issue 19 Pages 2877-2880

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Abstract

A 35-year-old non-HIV patient developed pulmonary cryptococcosis after the initiation of infliximab. He recovered by fluconazole treatment and completed the therapy for a total of 6 months. However, he experienced a relapse 16 months later during retreatment with infliximab, revealing an interesting clinical course contradicting retreatment. This case also represents the first case of relapsed pulmonary cryptococcosis suspected during treatment with a biologic agent. Both of these aspects generated important clinical questions about the length of pulmonary cryptococcosis treatment and the necessity of introducing a second prophylaxis for such patients.

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© 2016 by The Japanese Society of Internal Medicine
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