Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
Two Cases of Acute Disseminated Encephalomyelitis Following Vaccination Against Human Papilloma Virus
Kenji SekiguchiNaoko YasuiHisatomo KowaFumio KandaTatsushi Toda
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ジャーナル オープンアクセス

2016 年 55 巻 21 号 p. 3181-3184

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We herein present two cases of acute disseminated encephalomyelitis (ADEM) following vaccination against human papilloma virus (HPV). Case 1 experienced diplopia and developed an unstable gait 14 days after a second vaccination of Cervarix. Brain magnetic resonance imaging (MRI) showed an isolated small, demyelinating lesion in the pontine tegmentum. Case 2 experienced a fever and limb dysesthesia 16 days after a second vaccination of Gardasil. Brain MRI revealed hyperintense lesion in the pons with slight edema on a T2-weighted image. Both cases resolved completely. It is important to accumulate further data on confirmed cases of ADEM temporally associated with HPV vaccination.

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© 2016 by The Japanese Society of Internal Medicine
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