Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Feminizing Adrenocortical Carcinoma with Distinct Histopathological Findings
Masako HatanoYasuhiro TakenakaIkuo InoueKeiko HommaTomonobu HasegawaHisanobu SasanoTakuya AwataShigehiro Katayama
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JOURNALS OPEN ACCESS

2016 Volume 55 Issue 22 Pages 3301-3307

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Abstract

We herein present a 60-year-old man with adrenocortical carcinoma who had gynecomastia. An endocrinological examination revealed increased levels of serum estradiol and dehydroepiandrosterone-sulfate (DHEA-S) and reduced levels of free testosterone. Magnetic resonance imaging showed an adrenal tumor with heterogeneous intensity. Iodine-131 adosterol scintigraphy showed an increased uptake at the same site. Because feminizing adrenocortical carcinoma was suspected, right adrenalectomy was performed; the pathological diagnosis was adrenocortical carcinoma. The results of immunostaining indicated a virilizing tumor. Aromatase activity was identified on RT-PCR. As disorganized steroidogenesis is pathologically present in adrenocortical carcinoma, this diagnosis should be made with caution.

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© 2016 by The Japanese Society of Internal Medicine
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