Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
An Autopsy Case of Amyotrophic Lateral Sclerosis with Diaphragm Pacing
Hisashi ItoTetsumasa KameiSanae OdakeMasayuki NakanoRiki OkedaShunsaku KohrikiJun KawachiRaymond P. OndersFumihito Yoshii
ジャーナル オープンアクセス

2016 年 55 巻 23 号 p. 3511-3513


Respiratory insufficiency is a critical problem in amyotrophic lateral sclerosis (ALS) patients. We herein present the case of an autopsied patient with sporadic ALS who underwent diaphragm pacing (DP). The pathology showed several localized adhesions with a markedly atrophied diaphragm. A marked loss of motor neurons with Bunina bodies and phosphorylated TDP-43 positive inclusions was found in the spinal cord and primary motor cortex. Mild hyalinization and a few multinucleated giant cells were present around the electrode tracks in the diaphragm. However, no infiltration of inflammatory cells was detected. Our findings suggest that full-time DP might not cause severe damage to adjacent diaphragm tissue.

© 2016 by The Japanese Society of Internal Medicine
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