Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
CASE REPORTS
High-frequency rTMS for the Treatment of Chronic Fatigue Syndrome: A Case Series
Wataru KakudaRyo MomosakiNaoki YamadaMasahiro Abo
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ジャーナル オープンアクセス

2016 年 55 巻 23 号 p. 3515-3519

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Structural and functional abnormalities of the prefrontal cortex seem to correlate with fatigue in patients with chronic fatigue syndrome (CFS). We consecutively applied facilitatory high-frequency repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) of seven CFS patients over three days. Five patients completed the 3-day protocol without any adverse events. For the other two patients, we had to reduce the stimulation intensity in response to mild adverse reactions. In most of the patients, treatment resulted in an improvement of fatigue symptoms. High-frequency rTMS applied over the DLPFC can therefore be a potentially useful therapy for CFS patients.

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© 2016 by The Japanese Society of Internal Medicine
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