Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Acquired Factor V Inhibitors in a Patient with End-stage Renal Disease
Atsushi KitazawaHideo MisawaKatsuhiro NagahoriRyo KodaAtsunori YoshinoShinya KawamotoTetsuro Takeda
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ジャーナル オープンアクセス

2016 年 55 巻 23 号 p. 3505-3509

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We report a case of acquired factor V inhibitors (AFVIs) in a patient with end-stage renal disease receiving warfarin therapy for atrial fibrillation. A 72-year-old Japanese man was admitted to our hospital complaining of tarry stools and abdominal pain. The laboratory findings revealed eosinophilia (52.1%), prolonged activated partial thromboplastin time (APTT) (98 s), PT (84 s), a factor V (FV) activity of <3%, and an FV inhibitor level of 6 Bethesda units/mL. After administration of prednisolone was started, his coagulation findings improved. However, his renal failure progressed, and he ultimately required chronic hemodialysis. This is the first case of AFVIs in a patient starting hemodialysis for end-stage renal disease.

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© 2016 by The Japanese Society of Internal Medicine
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