Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Post-Transplant Membranous Nephropathy Associated with Chronic Active Antibody-Mediated Rejection and Hepatitis C Infection after Deceased Donor Renal Transplantation
Tomohito DokeWaichi SatoKazuo TakahashiHiroki HayashiSigehisa KoideHitomi SasakiMamoru KusakaRyoichi ShirokiKiyotaka HoshinagaAsami TakedaYukio YuzawaMidori Hasegawa
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JOURNALS OPEN ACCESS

2016 Volume 55 Issue 4 Pages 375-380

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Abstract

A 53-year-old woman who had undergone deceased donor kidney transplantation twice, at 35 and 43 years of age, presented with renal impairment. She was infected with hepatitis C virus (HCV). The histology of the graft kidney revealed post-transplant membranous nephropathy (MN) with podocytic infolding and antibody-mediated rejection (AMR). IgG subclass staining showed fine granular deposits of IgG1 and IgG3, but not IgG4, in the glomerular capillary walls. Panel reactive antibody scores for human leukocyte antigen class I and class II were 92.67% and 66.68%, respectively. Thus, this case of post-transplanted MN was considered to be associated with AMR and HCV infection.

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© 2016 by The Japanese Society of Internal Medicine
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