Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
CASE REPORTS
Acute Exacerbation of Idiopathic Pulmonary Fibrosis Following Treatment for Cushing's Syndrome
Nobumasa OharaMasanori KanekoKazuhiro SatoHiroyuki UsudaJunta TanakaTakashi MaekawaHironobu SasanoHideki KatakamiKenzo KanekoKyuzi Kamoi
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JOURNALS OPEN ACCESS

2016 Volume 55 Issue 4 Pages 389-394

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Abstract

A 64-year-old Japanese man with mild reticular shadows in both lungs developed a lung tumor causing ectopic Cushing's syndrome. He was prescribed an adrenal inhibitor, which controlled his hypercortisolemia. However, he developed acute exacerbation of idiopathic pulmonary fibrosis (IPF) and died within weeks. Previous studies have suggested a dosage reduction of corticosteroids for IPF as a triggering event for acute exacerbation. The present case suggests that IPF coexisting with Cushing's syndrome may have been exacerbated after the correction of hypercortisolemia. Therefore, close monitoring of cortisol levels along with the clinical course of IPF is required in similar cases that require the correction of hypercortisolemia.

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© 2016 by The Japanese Society of Internal Medicine
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